Over the years I have shot a lot of 125gr JHP bullets out of 6" S&W revolvers.

In my newer 686 6" that I did a lot of testing in, I did well with the Winchester and Hornady bullets over all.
My best light 81% of maximum target loads were with W231 and CFE pistol powder that did around 1220fps.

SR4756 and 2400 at 1448 and 1502fps did best in the accuracy department at the full load area.
I don't have any slow ball powders.
The new BE86 shot well with the XTP JHP but the max loading only reached 1307fps, in my revolver
which fell a little short of my Unique powder tests, at 1355fps.

Maximum loads are nice now and then but I sure enjoy the accuracy
at the range or chasing jack rabbits with the lighter load at just 1200fps +/-
for a longer session of shooting.