" Most everything I am finding is talking about using lead cast bullets, which I'm not interested in doing."

And why is that? At typical Schofield velocities and from a 2" barrel, most jacketed bullets would be unlikely to expand much if at all, and of course lead bullets are much less expensive. A lead .45 bullet is plenty effective for any defensive purpose.

For 180-200 grain lead bullets in the Schofield case, I'd recommend starting at 5 grains of Bullseye. That will be very safe. If recoil is too much, drop down to 4.5 or 4.