I have a customer that regularly challenges me to shoot my 340PD and he with his 340M&P offhand at 75'-150'. We each shoot a couple of boxes of handloads or factory 38sp usually in three round segments. I have the Crimson Trace LG405 grips and he uses the stock S&W rubber. After one gets unto the rhythm neither of these guns are painful and the challenge of shooting at that distance if great training.
If you want a snubbie to drop in a good pocket holster and literally forget it is there, go for it. If you want a range gun or a dedicated house gun, go for the all steel 640 or a Kimber K6s.