You did not state what frame or model 357..........
but all powders are SAFE if you follow the manuals data.
Trail Boss and Red Dot will do great for any lead target loads.
The 4227 powder will work with low fps lead and medium high Jacket loads.
Just that you use a lot of it to get the job done vs some of the other faster powders but it is very safe, in the 357.
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