Remove the screws, USING A HOLLOW GROUND GUN SMITHING SCREWDRIVER, hold the revolver with the side plate up and then tap the grip frame with something soft, like a wooden hammer handle or the handle of a screwdriver. The side plate will work itself off.

If you remove the cylinder, beware there is (or was) a spring loaded pin in the yoke. This is a cylinder hold open devise. It will probably be stuck with old gummed up oil, but it could be free and shoot out if you're not careful.

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John 3:16
WAR EAGLE!