In the late ‘70’s I tried different reloads looking for the most accurate round for my 6” barreled colt Python. The 125 through 158gr the JHP.
My most accurate load out to 100 yds with the 6” barrel was the Speer 140gr JHP bullets using 2400 powder. In my police service six With the 2 3/4” barrel I carry the 140gr jhp’s. It’s my only snubby revolver.

I’m not fond of short barrels but my s&w m58/4” barrel is gaining popularity with me.