I happen to like .380s and have several. For me its more about the gun than the cartridge. However I do believe the .380 will get the job done and I do carry one from time to time.
For a pocket size .380, I think the Colt Mustang can't be beat. Mine have been totally reliable, accurate, and the locked breech design makes racking the slide and recoil easy to handle.
With me being a 1911 guy, the manual of arms is quite natural to me.
For the record, I very rarely pocket carry. It just don't work for me. Even when I do pocket carry, its most often a jacket pocket where I just drop the gun in for a quick trip to the store or such.
But in a good holster the little Mustang just disappears and you don't even notice that you're carrying it.