If weight is not really much of a consideration, carrying a combo of something like a Glock 19 and an hammerless snub revolver would provide effective tools for an extremely broad range of possible defense scenarios. Most would consider the G19 the primary and the snub the backup, but I would look at the snub as the main weapon to have immediately accessible due to its efficiency in reactive close-quarter situations.

However, I just don't see that combo being necessary for civilian self-defense and carrying relatively heavy gear takes its toll over the course of years.

In terms of lighter guns, I'm just not a huge fan of small autoloaders since most are pretty finicky and their capacity is usually not all that much greater than the revolver to make it a sensible consideration to trade-away the reliability, safety and ECQ advantages of revolver.

My carry choice is a lightweight, small frame wheelgun.