The answer is: It dosen't matter! Carry whatever you feel most comfortable with and whatever system you will actually carry. The first rule of gun fighting is to make sure you have a gun. That 686 is a nice gun but does you no good if it's home in your sock draw because it's too heavy. Your Glock is one of the most reliable semi autos ever devised but if you leave it home because it's too thick to carry in your waist band, it's useless. The next rule of gunfighting is to hit your target. That 1400fps, 125 grain, 357 is useless if it goes whistling off into the landscape when you need to defend yourself. You are better off with a center mass hit from a 40gr .22 than 5 misses from your 500 magnum. This is the long way of saying that you need to concentrate more on HOW you are carrying than WHAT you are carrying.