It depends on the rifle, I favor the 220 swift. I don't run them
the advertised 4110 FPS because I shoot 55gr bullets instead
of 50s that ammo companies use for advertisement. Most 220s
are heavy barrel which every thing being equal is not that much
different than 22/250. You do encounter a lot of 22/250s with
Sporter wieght barrels and even some ultra lites. These rifles
can be very finicky and usually have bedding issues. A 222 or
223 with 55gr running 3250fps are solid 300yd groundhog guns.
With HB Swift I had a field where I regularly made 400-500 yd
shots. My serious ground hog gun is a Custom 98, Douglas berrel
Canjar trigger and stocked as bench gun. I shoot 85gr BTSP in
It. Longest shot I ever made was slightly over 600yds with it
The Swift I would say approx 450.

Before the coyotes ate them all we shot groundhogs several
night a week to everyday if weather was right. You shoot for
500, the local official bragging quota. You shoot so many I is
hard to remember a shot unless it was special. Like Exteme
range or some fluke out of the ordinary. I live were I can start
shooting a 100yds from house. Everyone had a groundhog gun.
90% of the were Rem 700s or 788s in 22/250. 90% of them are
shooting factory ammo. There are a lot of 22/250 being traded
in on Ohio Legal Deer guns.