I've shot a whole lot of souped up magnums. Multi thousands of 265g home cast GCSWC over 22g W296/H110. I figure I was making ultra premium ammo since the early 80's. Buffalo Bore type stuff, because I could.

I actually bought a 44 that came with a box of 50 rounds missing 6.

That said, 44Spl pushing a 250g Keith @ 850 ~ 900fps is sublime in a purpose built 44Spl N frame.