Had a Ruger Single Six when I was a lot younger and had great eye sight and rock steady nerves.

The 6" barrel was pretty accurate out to 25-30 yards on "Vermin"
that came into range while driving the gravel back roads in Calif.
in the Sac. Valley, when we were almost old enough to drive a jeep.

Only problem , there is no place to rest the pistol for a right angle shot !!
Lots of the pest got off easy for the return trip or next visit.

Never lucky enough to get to try it out in a rifle.