For those having strong interest but have not yet bought a 22 RFM handgun, my reply may be useful.
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Decades ago my father bought a High Standard over/under derringer in 22 RFM. Muzzle blast from yellow boxed Winchester hollow points was awe inspiring, and a sheet of fire blasted out about two feet. The short-barreled derringer was so unpleasant to fire, he disposed of it in favor of a two-inch barreled Combat Masterpiece that he kept until his death.

While I do not have experience with longer barreled handguns in 22 RFM, it would be prudent to shoot it in conditions of intended use. That is, if it's for personal defense, shoot it indoors and out doors without ear protection. If woods-walking carry gun, outdoors will do you well.

Hope this helps.