Should you shoot the "unfired" safe queen or not?

It's a question that is debated without end on this site because there's no right or wrong answer to that question.

If you have a high-condition gun that looks unfired since it left the factory, how much does shooting it affect its value?

There's no right or wrong answer to that question, either.
Valuations fluctuate quite a bit, even on those high-condition guns.
It also depends on how often it's shot and with what ammo.
How it's cleaned and stored, how rare it is, etc.

However, condition is everything to a lot of buyers and it will affect value. How much is hard to say.

To many buyers, they're only interested in stock, 98 - 99% guns.
The LNIB type.

That's what I look for. And I'll pay a premium for them.

I've shot most of the ones I have purchased, with only a couple of exceptions.

These types of threads are fun. Almost as fun as bear threads!