A .22 short is enough, just put it though an eye socket. A .22 LR will probably penetrate the skull. More people have died from the .22LR than any other round. .32acp fmjs penetrate a torso, A .380acp properly placed will work just fine.

I carry a .38 special, it has a proven track record. .38 Super and .357s even more so, but with a huge sound signature.

.40S&W, .44 specials, .45acps can both kill and cause significant injury even with pariphreal hits.

JMO, rule one always carry, rule two hit what you aim at.

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Certified Curmudgeon