If you do the math, you'll find the 44Spl and the 45LC are pretty similar.

44Spl 250g SWC 900fps

45LC 255g SWC 900fps.

So, there is a difference, small though it may be. 44Spl is .429 and 45LC is .452, so the diameter of the 44Spl allows for better SD, BC and that translates into better accuracy and penetration. Admittedly, this is empirically different, not noticeable for most folks.

Still, the 45LC is the "magnum" of its day and famous for its service in the West. This means that the 44Spl is pretty much the same thing.