I'll start with this...I have not had a chance to handle a Cobra as of yet...I will as soon as I come across one.

...but...

Looking at the competition in that range, the Colt leaves me with a "why bother" feeling. Look at the field (using pricing from Buds):

Ruger SP101 26oz .357 magnum, $565
Colt Cobra 25oz .38 +P $675
Kimber K6 23oz .357 magnum $833
S&W model 60 21.4oz .357 Magnum $618

Now, I'm no huge fan of Kimber...but that K6 is a superb (be it ugly) revolver. I have handled one and the fit/finish/trigger on one is superb. I owned a Sp101 for years and it was a great small revolver. I have not handled a Model 60...but it is a S&W so I'm guessing I'd know what to expect with a factory gun.

The 800lb gorilla in the room here is the fact that the Colt is .38spcl only vs the other three.

If I were in the market for another 25oz range, I wouldn't even spend the time looking at the Colt, it's more costly than the Ruger and the S&W and can't handle magnum ammunition.

Just my $.02...