Didn't James Bond carry a Beretta .22 caliber semi automatic originally? at least until he was ordered by M to turn it in for a Walther PPK.

The .22 LR has a lot of energy and the bullet will richochet around in the body of the victim causing maximum damage.

I have read that Mafia assassins carry .22LR caliber pistols.

My first revolver was a Smith Kit gun in .22 LR with 4 inch barrel when I was 10 years old. I learned early to respect the .22 LR.
No kidding!