I would be shocked if Colt didn't bring back the Python, especially when there is renewed interest and demand for it ever since it was featured in The Walking Dead.

That being said, it will most likely be denigrated at every turn by self-interested individuals who have "invested" in an original Python and fear that a reintroduction will make theirs more difficult to sell, as was the case when Colt reintroduced the Cobra.
Obviously cost-saving measures will be implemented in order to make the Python more affordable/profitable, which owners of the classics will make a huge deal over, regardless of the fact that they would have never bought a new model anyway in a desperate attempt to "protect their investment" which has most likely been relisted countless times on gunbroker for an exorbitant price that no one will ever be interested in paying, but they'll never budge because that's how much it is worth in their dollar-sign-obscured-eyes, and they'll take it to the grave at said price.

It's coming.

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Shooting Comfort is bilateral.