Well, at the risk of disappointing any of my valued, fellow Third-Gen aficionados here, I'll be up front and say that I don't carry one or regularly shoot one as so many of you do.
I do, however, always carry them to the range when I go (which is not as often as I'd like), and my round of choice is "God's caliber." It's what is loaded in my HD gun -- the WVSP 4566TSW I found recently -- that makes me feel well-protected in my castle and don't hesitate to bring along if I'm traveling.
What I have with me every day is a Kimber Micro-9, primarily for its size, weight, and acceptable capacity given the largely non-threatening environments I frequent.
Of course, in my heart of hearts, I'm an S&W guy all day long.