My sole experience in using LR primers for handgun loads involved reloading .44 Magnum for use with a .44 Ruger Super Blackhawk. It didn't work. The primers protruded far enough above the cartridge base that those rounds tied up the cylinder. i.e., not enough headspace. It would not rotate with those loads. And I wasn't about to try to mash those primers deeper into the primer pocket.

Not to say that by using another revolver, another brand of cases, and/or another brand of LR primers it might work OK, but it seems imprudent to try. Why not just use the correct LP primers and not worry about such things?