That is a pretty gun you got there, dr. mordo. But I bet it kills on one end and maims on the other with 500 grain solids.
I just looked over at the Hodgdon website and they show a couple of Trail Boss loads for some cast lead bullets that I bet would make for some fun range play though. And I would think that some 350 grain Speer Spitzers would make for some ammo you could hunt big deer or black bear with and I would guess recoil might be a little milder with.