A few years ago I loaded .44mag. cases with Hornady XTP 240 HP.
Powder was H110. I knew my Nephew would use them only from his Ruger SRH . So I maxed them to a 24.4 gr. charge. With no visible pressure signs/primer back out was nill.
We practiced , and got accurate and confidant enough to hunt with handguns only.
Went to an exotic game Ranch, where the Nephew bagged a Big Corsican Ram with the Ruger and my home rolled.
He hit that Ram after a slow stalk and Native American type crawl. Got about 45 yards, and let the power loose.
Ram never knew what hit him. Bang & Drop... Not a step.

(BTW. I bagged a feral Boar . 45-70 from my TC/Contender pistol ) .

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Dino in Pittsburgh's Rat Pack