.45 ACP/modernized smokeless powder version of black powder .45 colt is an excellent round, as was it's predecessor. However shot placement is what wins, .093 wider won't turn a bad hit into a good one. I know a couple of people who killed black bears w/ .22's* just as quickly as a bazooka would but given a choice would have jumped @ the chance for a .45, .357, .30-06, etc.
*bullet down ear canal, long story for another thread.