I did do a work up with N110 with a 125gr Sierra bullet in the 4" 686 some years back. 18.0grs was as far as I should go. I got around 1365-1380 fps, depending on ambient temps. With the 125gr bullet weight, it didn't keep up with 300-MP or H-110/296. for velocity yield. But, the powder is clean and provides decent accuracy with not a great deal of flash. When we burn this much powder in this length barrel, some flash will always be present. It does a good job with 44 Mag as well.

I have often found VihtaVuori data to be rather optimistic with their numbers. A good chronograph set up properly will tell the real story..

As a side note, you might find this interesting..
I like to do 'pull-downs' with various factory loads, and post them over at the 10mm Forum. The particular round is examined and shot for accuracy. Here is some 357 125gr factory loads;

357 Mag Winchester 125gr JHP Super X - Factory Ammo pull-downs - 10mm-firearms.com

357 Mag REM-UMC 125gr JSP - Factory Ammo pull-downs - 10mm-firearms.com

357 Mag Federal 125gr JHP - Factory Ammo pull-downs - 10mm-firearms.com

357 Mag BuffaloBore Heavy 125gr JHP 19D - Factory Ammo pull-downs - 10mm-firearms.com

A few years before I standardized this method I looked at the Gold Dot 125gr factory load;

https://i.postimg.cc/yYRNKpxB/Speer125-GD.jpg
https://i.postimg.cc/TYDz1Zn7/Speer20-8grs.jpg
https://i.postimg.cc/1XQDkh2q/Speer-GD-125gr.jpg

So, we see that Win, Rem, and Fed ammo is loaded with 19.5-19.8 grs of a non-canister ball powder.

The Gold Dot load contains 20.8grs of ball powder.

The BB contains 22.4 grs of what ever that is. That is close to Alliants recipe with 300-MP for 125gr bullet weight, but I can't come close to the velocity I get with the BB ammo using 300-MP..
When you light one of those BB rounds off, you know something just happened!

So we can see the main line factory loads, Win, Rem, Fed are loaded rather mild in comparison to 22.0grs of H-110/296.

As you have well stated, having these max loads are fun for occasional use, a steady diet could prematurely ware a gun out.

I lived in LA way back when and went out to the desert to shoot often. Fun times. Have fun.