The bigger 45 ACP cartridges allow my big arthritic mitts to handle them better, and also with aging eyes, I can see the bigger holes which they put in paper targets better compared to smaller bullets.

...kidding aside, a fantastic cartridge. One can have their entire handgun needs covered by 22lr, 38/357 and 45 ACP. Add in a 41 or 44 Magnum for bigger game if you so desire.