The new 19 and 66 are as strong as the L-frames. Stoke them up as hot as you want with any bullet weight. Barrel erodes eventually? No problem with the separate barrel and shroud, replace the barrel only and no one's the wiser.
If I were going to shoot really hot loads I'd go 4.25" just because the muzzle blast and noise from a snub is so obnoxious.
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