I carry the first round up ( or two) in .45 Colt with shot shells here in warmer weather. If the first or second round are shot shells, capsule creep is not a problem.
If I fired several solid bullet rounds first, then yes, the capsule would start creeping out.
As much as I like carrying one of my single action revolvers in .45 Colt, I find myself packing the .45 Shield a lot lately.
It is thinner, lighter, and more comfortable to pack, but still has 8 rounds of .45 Auto on tap. Also, for camping trips, it has night sights and a small 100 lumen light and green laser, while my revolvers do not.
The Shield shoots the CCI .45 ACP shot shells as reliably as FMJ, and will sever the head of a rattlesnake no problem.