I have found the 99.9% of snakes shot, chopped or clubbed are secondary reaction. You would have to be mighty fast to outdraw a striking snake. I think highest value of shot loads is to kill snakes and other vermin in places you can’t use a bullet. I’ve personally not had the rimfire type work loose.
357 yes but only once. The hand loaded 357 and 44 are prone to walk. I was putting light coat fingernail polish in case mouth and that helped some.
I quit carrying them in gun and just carried cast bullet for snake load.