With the load you mentioned, .1 grain deviation isn't much and won't be a problem. However, if you later start loading a really fast powder in a small caliber such as .25, .32 or .380, your powder charge could be very small. A .1 grain deviation could be a problem. As an example, .25 ACP with a 35gr jacketed bullet and Titegroup starts at 1.5 gr with a 1.7 gr max according to the Hodgdon web site. Size matters.