Maybe, maybe not.

Lots of factors. I've seen reports of people saying they've put thousands of rounds through their 442s/642s without a problem. So the possibility is certainly there.

But it might not. My first 642-1 went about 1500 rounds, about 1/3 of that +P, when the hammer stud broke. S&W replaced it under warranty. What I don't know is how common something like that is. I could've just had bad luck.

I would say use it as you normally would. Inspect it regularly. Clean, lube, and maintain it properly, and it should last a long time. Will it last long enough to be a heirloom gun? I can't say, and I'm not sure anybody can say with any real accuracy. Despite the strength improvements of the new airweight guns, overall I don't think they're as durable as all-steel guns, even if the gap between them has gotten smaller.

Just my opinion.