If you have a proper fitting solid tip screwdriver or bits that you can use to carefully remove the most forward screw on the right side of the revolver, taking this screw out will allow you to remove the yoke and with it, the cylinder will come off the yoke.

I personally believe that it is better to pull the cylinder from the revolver rather than put frenetic forward energy in to scrubbing chambers while the cylinder is mounted.

Others may disagree.