25 grs of 4227 with a 240 gr jacketed bullet is’t “Way Hot” according to Lyman manuals. It’s listed as a factory duplication load. For the best velocity from a rifle or handgun with a 240 gr bullet use 24 grs of 296/H110 and a magnum primer. Chronos at a little over 1800 FPS out of my Ruger #3 single shot 22” barrel.