If we’re talking about Doug Guy, he’s great.He has done a few pistols for me, and it solved my problem, and will probably solve yours, too. Some 45s don’t have an adequate leade in the barrel, and depending on the shape of the bullet may not seat into the chamber all the way. 250 grains is pretty heavy for a .45 ACP. You can try seating your bullets a little deeper, and that may solve the problem. OAL length as listed in the manual is just a starting point, and tells you the OAL length they used to come up with their data. The correct length is one that will “plunk” all the way into your barrel, and fall out under its own weight.
Also, make sire you are getting all the flare out of your cases.
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Good luck, and let us know how you make out.