Yes, IMR 4227 is a very versatile powder, good for lighter loads in bottleneck rifle cases and full loads in straight cases (including handgun Magnum calibers). Probably at its best for use with lead bullets in rifles. I started loading .45-70 using 4227. My favorite lead bullet load for both the .308 and .300 Savage is around 23-24 grains of IMR 4227 with a 170 grain lead bullet. That will produce about 2000 ft/sec in both with good grouping performance. Similar to, but slightly slower than, H110 and 2400. It is one not to pass up if you can find any at the right price.