It will depend on what type of loads that you like to shoot.

95% of my 38 & 357 loads are light target to medium light loads that will
take care of SD work if needed..........
so the fast powders to the medium burn like w231 should work for most loads.

Unique with lead or 2400 or slower powders with a copper jacket will give
you any full load that will work for SD or a 357 hunting load.....
and a pound of powder will load a lot of "Hand jerkers".

Good luck.