One thing you need to mention is your barrel length. If you're shooting 3 to 5" barrels there's no point in loading slow powders like H110/W296 because a large amount of powder will burn outside the barrel.
The other key point is amount of powder in the case. These slow powders DO NOT perform well at less than near full case levels. If you want medium velocity Unique is very good and many other powders fall into the same level. Depends on what you've got on hand.
Have fun!
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Bob.
SWCA 1821
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