With the velocity range you are trying to gut, 4227 is going to leave a mess behind... Not sure where you should start with Blue Dot but with Unique I use 18.0 grains with a 350 Berry's plated bullet and get 1050 fps. 20.0 gets 1225 with a Sierra or Hornady 350. This is out of a 4"...very pleasant shooting loads.
If you start with the same loads with a 300 you should be in the same velocity area...
Bob
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