As a general rule, if one seeks out Dr. Roberts' duty ammo testing/recommendations, then finds one of those loads in sufficient quantity (500+ without a malfunction) to function test the platform(s) from which you, the odds are very good that you have solved the ballistic question. That is actually the easy part.

One must develop the right mindset and skills to implement it, and maintain those. As for home defense, the important stuff is to make your home uninviting to others: Fencing, lights, dogs. If you make the hostile go elsewhere because they don't think bothering you is a good idea you are ahead of the game. This will discourage the vast majority of those who might present a threat. The odds are pretty good that if have to shoot an intruder, you have not taken the proper preliminary steps.

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NHI, 10-8.