As another poster pointed out, it depends on what the criterion for "best" is: best-shooting, best-looking, most powerful, best-carrying, most accurate, most popular, most valuable, etc. But as Mike Priwer pointed out, the M&P series made the company what it is, so the 38 M&P gets my vote. If I had to pick just one version, I'd say the 4" 10-5 with PC magnas, but I dearly love all of the variations from the first model of 1899 to the early M&P targets, to the 14 and 15, and other K frame variations (though the current production HB Model 10 with goodyears and lock might be the last gun I would buy, and only if it was the only one I needed to complete my collection!). -Donald