.45s are authorized by the Bureau but it wouldn't have been a good choice for standard issue...simply a size and recoil issue.

Glock 22s are actually big enough that a significant portion of the female agents simply can't conceal them properly..same for some of the smaller men. Right now most are getting a G23 to help with that. It's not a big difference in size, but it's a big difference in concealability.

For the women and men with smaller hands, the G22/23 is about the largest grip size they can shoot well. Going to a G21 wouldn't work at all for many of them and the additional recoil would only make it worse. R,

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USPSA TY23298