Was loading up the last of my .45 Colt brass and grabbed a loose box of Winchester standard large rifle primers instead of large pistol primers. I didn't notice the mistake until after I was done and was cleaning my bench off. The end result is that I now have 100 loaded rounds with large rifle primers in them. These loads are my "Cowboy" loads, 250gr. lead rnfp over 7.1 grains of Universal Clays.

So the question is, what is the difference between rifle and pistol primers? Enough to cause a difference in pressure? Go ahead and try and shoot them or get busy and start pulling apart 100 rounds?