Here's a topic that anyone with an opinion could write a book on - and likely make their case.

I've used this round my entire adult life, one way or another, from several different platforms. I think it is a groundhog cartridge. Results on people reflect that. The old GI 55 grain load works pretty well for some things, the newer greentip is better for others.

Like everything else, blow out the brain, break the neck or spine high up and they will drop. You gotta turn off the electrical generator or major transmission lines to get quick success. Other than that, you are depriving them of oxygen by bleeding them out and that can take a while. It doesn't matter if you are shooting a .22 or 20mm.

The wild cards are extreme anger, drugs or adrenalin. In which case you blow out the brain, break the neck or sever the spine high up etc.

Best of all is never having to go there and all of this stays in the realm of speculation.