I am guessing you meant for non-paper "targets?"

Theoretically, if you included some better-penetrating rounds and some faster expanding rounds in a mag, you are equipped for alternative situations, but I think this is mostly armchair kind of stuff.

I have from time to time thought of carrying deeper penetrating ammo in the winter due to the chance of an attacker wearing more clothes, but have instead just tried to use a good compromise all the time.

I could see some merit if someone alternated 124 grain ball with similar velocity 124 grain hollowpoints, if there was truly a reason to worry about penetration issues. At least point of impact wouldn't change much.

I don't think I wold bother.

__________________
I see dead people