Been in love with wheelguns since I was real small. Carry a 686P 4" now and love it's accuracy, feel and versatility. For household defense you can use .38+P. During my numerous yearly forays in the Eastern Sierra Nevada, Buffalo Bore 125 to 180gr loads give a lot of versatility you just don't find in a semi-auto.

As for the capacity argument, if you can't get the job done in 7 rounds, it just isn't going to be your day. Also, if you really want to play the combat reload game, with practice and moon clips you can match any semi-auto hot shot (check out the Miculek videos).

However, when all is said and done, you either did it right whatever your carry, or you're six feet under. I'd personally prefer not to be shot at with either a wheelie or a semi.