Pow'rBall is great for those guns that need a RN configuration to feed/function reliably and have a very potent capability. I've used Pow'rBall in sub-compact 9mm just to have the extra edge in reliability, not necessarily capability, however, I'm completely comfortable with carrying Pow'rBall as a primary SD round. Despite its light weight in every caliber, compared to other manufacturer's lines, it has high energy ratings and very impressive penetration results in ballistic gelatin. I don't personally know of any actual shootings, but I'm sure they are out there.
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