I've worked a bunch of different homicides with a bunch of different weapons. The only "weapon system" that was 100% fatal was the common .22 repeating rifle. Most of my time was on Indian reservations, so that was the handiest thing around when the killing started, but if somebody starts poking holes in you with their trusty Marlin Model 60, your day is at an end.
Pistols were hit and miss. I used to be on a fugitive squad in New Orleans and almost everyone I arrested had been shot at one time or another. To kill time on the way to Central Lockup I would ask them about what they had been shot with, and they were usually more than happy to point out healed and mostly healed bullet holes and say: This one was a 9, or this one was a forty. One guy was missing almost all of his left calf which he claimed was from an AK round. Didn't stop him from healing up and paying back the favor.
I think the best deal going is .40 police trade ins. Its like when those obsolete .30/40 Krags hit the market way back when for next to nothing. Those guys back then probably said - what do I want a clunky old thing like that for? Meanwhile, other guys were socking them away.
Now is the chance to be the other guy.