IIRC, I loaded both the Speer 55gr HP and SP for my 22-250 and they were both equally effective on groundhogs. I actually thought I was a bit over gunned at the ranges I was shooting near E. Lansing, and used that as excuse to buy a M70 .223 varmint. Of course the reloading bug had bit and I had to have the newest thing, Nosler BT's.
While the Speer bullets killed them, the BT's blew them to pieces.
I still have several boxes of the Speer bullets, I do reload more BT's.
But the bottom line: "dead is dead!"