I load for the .45 Colt but not the 45 S&W but my buddy load Schofield loads. Like me he uses several powders which work well, W231, HS-6 and Universal but he likes W231 best. With a 230gr bullet he charges 5.6gr W231. I used to load mostly W231 in my .45 Colt but I found myself changing over to HS-6 lately. All 3 powders are good choices IMO and you can add AA#5 and Unique to the list too.
Hope this helps...
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