Most scales are not as accurate as your measurements. The average warrantee is +/- 2/10ths grain. I have 7 scales I use certified check weights to verify their accuracy.
I have a 30 year old Hornady scale that for some odd reason is well within a 1/40th of a grain. (1/4 of 1/10) When weighing long range rounds (308 Win., 300 Win. Mag., & 338 Lapua) I weigh every charge of extruded powder. I can see the that the powder granules are different sizes. Substituting larger or smaller granules can tune a charge as accurate as your instruments can measure! But the case, primer, and bullet all have a plus or minus. You can load 10 identical rounds (within you scale's tolerances) and the gun still may not shoot well! It could be you, it could be the gun, but very commonly some components don't like each other! (substitutes can make a huge difference!)
They only way to know what will happen with a new load combination is to take it to the range and shoot it. Your most accurate load to date is the standard you try to beat.
For rifles: different lot numbers of powder can change how accurate your gun shoots, but it is a small percent! (When IMR 8208XBR came out, the first and third batches of that powder were great, batch #2, not so much!) When starting out, I recommend you stay with time proven loads (Just because it is safe to shoot does not mean it will shoot well!) I went through 6 different powders before I found a good powder for 1000 yard 338 Lapua Mag! (ended up using H-1000! .25 MOA @ 1000 yards!: that is 2.5 inches!) If I miss, it's me! not the gun or ammo!) All the powders I tried were highly recommended, by powder companies and magazine writers! 2 fellow shooters helped out with their pet loads.
For revolvers: the alloy of the cast bullet or the alloy of the jacket will make a big difference. Also when switching from lead to jacketed or switching back; get the gun's riffling completely free of the other metal!
Ivan